Assoc. Prof. Mag. Dr. Anna Weinzinger, Privatdoz
room: 2D178
tel: +43 1 4277 55311
e-mail: anna.stary(at)univie.ac.at
Research: Molecular modeling of ion channels
Teaching: more information
Publications
2026
Weinzinger, A, Kaiser, F, van der Heyden, M & Bendahhou, S 2026, 'Opening closed inward rectifier potassium channel doors', British Journal of Pharmacology.
2025
Handklo-Jamal, R, Raifman, TK, Shalomov, B, Hofer, P, Kahanovitch, U, Friesacher, T, Tabak, G, Tsemakhovich, V, Reddy, HP, Chomsky-Hecht, O, Tripathy, DR, Zuhlke, K, Dessauer, CW, Klussmann, E, Haitin, Y, Hirsch, JA, Weinzinger, A, Yakubovich, D & Dascal, N 2025, 'Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels', Nature Communications, vol. 16, no. 1, 11607. https://doi.org/10.1038/s41467-025-66730-8
Shalomov, B, Friesacher, T, Yakubovic, D, Carlo Combista, J, Reddy, HP, Dabbah, S, Bernsteiner, H, Zangerl-Plessl, EM, Weinzinger, A & Dascal, N 2025, 'Ethosuximide: Subunit- and Gβγ-dependent blocker and reporter of allosteric changes in GIRK channels', British Journal of Pharmacology, vol. 182, no. 8, pp. 1704-1718. https://doi.org/10.1111/bph.17446
Zangerl-Plessl, EM, Weinzinger, A, Nichols, C & Lee, S 2025, 'PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating', Journal of General Physiology.
Sauer, J, Marksteiner, J, Hohenegger, M, Todt, H, Kubista, H, Dostal, C, Kiss, A, Podesser, B, Salzer, I, König, X, Weinzinger, A, Hilber, K & Kudlacek, O 2025, 'The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels', American Journal of Physiology. Heart and Circulatory Physiology.
2024
Li, E, Boujeddaine, N, Houtman, MJC, Maas, RGC, Sluijter, JPG, Ecker, GF, Stary-Weinzinger, A, van Ham, WB & van der Heyden, MAG 2024, 'Development of new Kir2.1 channel openers from propafenone analogues', British Journal of Pharmacology, vol. 182, no. 3, pp. 633-650. https://doi.org/10.1111/bph.17377
Weinzinger, A 2024, 'In silico models of the macromolecular NaV1.5-KIR2.1 complex', Frontiers in Physiology, vol. 15, 1362964. https://doi.org/10.3389/fphys.2024.1362964
2023
Maksaev, G, Bründl-Jirout, M, Stary-Weinzinger, A, Zangerl-Plessl, E-M, Lee, S-J & Nichols, CG 2023, 'Subunit gating resulting from individual protonation events in Kir2 channels', Nature Communications, vol. 14, no. 1, 4538, pp. 4538. https://doi.org/10.1038/s41467-023-40058-7
Plessl, E-M, Wu, W, Sanguinetti, MC & Weinzinger, A 2023, 'Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate', Frontiers in Molecular Biosciences, vol. 10, 1137368. https://doi.org/10.3389/fmolb.2023.1137368
Weinzinger, A & Plessl, E-M 2023, Special Issue "Potassium Channels as Novel Therapeutic Targets". Pharmaceuticals.
2022
Garifulina, A, Friesacher, T, Stadler, M, Zangerl-Plessl, EM, Ernst, M, Stary-Weinzinger, A, Willam, A & Hering, S 2022, 'β subunits of GABAA receptors form proton-gated chloride channels: Insights into the molecular basis', Communications Biology, vol. 5, no. 1, 784. https://doi.org/10.1038/s42003-022-03720-2
Hackl, B, Lukacs, P, Ebner, J, Pesti, K, Haechl, N, Földi, MC, Lilliu, E, Schicker, K, Kubista, H, Stary-Weinzinger, A, Hilber, K, Mike, A, Todt, H & Koenig, X 2022, 'The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels', Frontiers in Pharmacology, vol. 13, 809802. https://doi.org/10.3389/fphar.2022.809802
Friesacher, T, Reddy, HP, Bernsteiner, H, Carlo Combista, J, Shalomov, B, Bera, AK, Zangerl-Plessl, EM, Dascal, N & Stary-Weinzinger, A 2022, 'A selectivity filter mutation provides insights into gating regulation of a K+ channel', Communications Biology, vol. 5, no. 1, 345. https://doi.org/10.1038/s42003-022-03303-1
Weinzinger, A 2022, 'Development of I<sub>KATP</sub> Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant K<sub>IR</sub>6.2 Based Channels for Treating DEND Syndrome.', Frontiers in Pharmacology, vol. 12, 814066. https://doi.org/10.3389/fphar.2021.814066
2021
Bründl, M, Pellikan, S & Weinzinger, A 2021, 'Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels', Frontiers in Molecular Biosciences, vol. 8, 711975. https://doi.org/10.3389/fmolb.2021.711975
2020
Qile, M, Golden, TD, Houtman, MJC, Weinzinger, A, van der Heyden, MAG, van Ham, W, Romunde, FL, Fransen, D, IJzerman, AP, January, CT, Heitman, LH & Delisle, BP 2020, 'LUF7244 plus dofetilide rescues aberrant Kv11.1 trafficking and produces functional IKv11.1', Molecular Pharmacology, vol. 97, no. 6, pp. 355-364. https://doi.org/10.1124/mol.119.118190
Chen, X, Bründl, M, Friesacher, T & Weinzinger, A 2020, 'Computational Insights Into Voltage Dependence of Polyamine Block in a Strong Inwardly Rectifying K + Channel', Frontiers in Pharmacology, vol. 11, 721. https://doi.org/10.3389/fphar.2020.00721
Plessl, E-M, Lee, SJ, Maksaev, G, Bernsteiner, H, Ren, F, Yuan, P, Weinzinger, A & Nichols, CG 2020, 'Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels', Journal of General Physiology, vol. 152, no. 1, e201912422. https://doi.org/10.1085/jgp.201912422, https://doi.org/10.1085/jgp.201912422
Plessl, E-M, Berger, M, Drescher, M, Chen, Y, Wu, W, Maulide, N, Sanguinetti, MC & Weinzinger, A 2020, 'Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574', Journal of Chemical Information and Modeling, vol. 60, no. 1, pp. 360-371. https://doi.org/10.1021/acs.jcim.9b00737
2019
Plessl, E-M, Qile, M, Bloothooft, M, Weinzinger, A & van der Heyden, M 2019, 'Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking', Biomolecules, vol. 9, no. 11, 650. https://doi.org/10.3390/biom9110650