Dr. David Gomez Varela
room: 2D351
tel: +43 1 4277 55361
e-mail: david.gomez.varela(at)univie.ac.at
Personal Homepage: https://homepage.univie.ac.at/david.gomez.varela/
Director of the Center of Excellence for Metaproteomics
Publications
2026
Sondermann JR, Barry AM, Xian F, Haberl T, Gomez-Varela D, Benseler F et al. Proximity Labelling Reveals the Compartmental Proteome of Murine Sensory Neurons. European Journal of Pain. 2026 Apr 26;30(5):e70277. doi: 10.1002/ejp.70277
2025
Grundtner S, Xian F, Malzl D, Radits T, Barry AM, Sondermann JR et al. Temporal and demographic patterns of peripheral nerve proteomes in preclinical neuropathic pain. Biomedicine & Pharmacotherapy. 2025 Dec 4;193:118855. Epub 2025 Dec 4. doi: 10.1016/j.biopha.2025.118855
Haiss P, Liu R, Xian F, Varela DG, Schmidt M, Dirsch VM et al. Evodiamine induces centrosome amplification with subsequent G2/M cell cycle arrest in primary vascular smooth muscle cells. Biochemical Pharmacology. 2025 Dec;242(Pt 2):117320. doi: 10.1016/j.bcp.2025.117320
Barry AM, Sondermann JR, Lesnak JB, Xian F, Franco-Enzástiga Ú, O’Brien JA et al. Multi-omic integration with human dorsal root ganglia proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway. Pain. 2025 Oct 1;166(10):2386-2402. doi: 10.1097/j.pain.0000000000003656
Xian F, Brenek M, Krisp C, Urbauer E, Kumar RKR, Aguanno D et al. Ultra-sensitive metaproteomics redefines the dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal diseases. Nature Communications. 2025 Jul 18;16:6644. doi: 10.1038/s41467-025-61977-7
Sondermann JR, Barry A, Xian F, Haberl T, Gomez Varela D, Benseler F et al. Proximity labelling reveals the compartmental proteome of murine sensory neurons. bioRxiv. 2025 Jun, p. 1-53. doi: 10.1101/2025.06.13.659475
Lohrberg M, Mortensen LS, Thomas C, Fries F, van der Meer F, Götz A et al. Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination. Journal of Neuroinflammation. 2025 Feb 23;22(1):47. doi: 10.1186/s12974-025-03368-9
Xian F, Brenek M, Krisp C, Aguanno D, Urbauer E, Srikumar T et al. Ultra-sensitivity metaproteomics redefines the gut “dark metaproteome”, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases. bioRxiv. 2025 Jan 10. doi: 10.1101/2024.04.22.590295
Grundtner S, Sondermann JR, Xian F, Malzl D, Segelcke D, Pogatzki-Zahn EM et al. Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia. Pharmacological Research. 2025 Jan;211:107552. Epub 2024 Dec 16. doi: 10.1016/j.phrs.2024.107552
2024
Urbauer E, Aguanno D, Mindermann N, Omer H, Metwaly A, Krammel T et al. Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease. Cell Host & Microbe. 2024 Aug 14;32(8):1347-1364.e10. doi: 10.1016/j.chom.2024.06.013
Barry A, Sondermann JR, Lesnak J, Xian F, Franco-Enzástiga Ú, O’Brien J et al. Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway. bioRxiv. 2024. doi: 10.1101/2024.12.06.626968
2023
Gómez-Varela D, Xian F, Grundtner S, Sondermann JR, Carta G, Schmidt M. Increasing taxonomic and functional characterization of host-microbiome interactions by DIA-PASEF metaproteomics. Frontiers in Microbiology. 2023 Oct;14:1258703. doi: 10.3389/fmicb.2023.1258703
Klén R, Huespe IA, Gregalio FA, Lalueza Blanco AL, Pedrera Jimenez M, Garcia Barrio N et al. Development and validation of COEWS (COVID-19 Early Warning Score) for hospitalized COVID-19 with laboratory features: A multicontinental retrospective study. eLife. 2023 Aug 24;12:e85618. doi: 10.7554/eLife.85618
Huespe IA, Ferraris A, Lalueza A, Valdez PR, Peroni ML, Cayetti LA et al. COVID-19 vaccines reduce mortality in hospitalized patients with oxygen requirements: Differences between vaccine subtypes. A multicontinental cohort study. Journal of medical virology. 2023 May 15;95(5):e28786. doi: 10.1002/jmv.28786
Segelcke D, van der Burgt M, Kappert C, Schmidt Garcia D, Sondermann JR, Bigalke S et al. Phenotype- and species-specific skin proteomic signatures for incision-induced pain in humans and mice. British Journal of Anaesthesia (BJA). 2023 Mar;130(3):331-342. Epub 2023 Jan 5. doi: 10.1016/j.bja.2022.10.040
2022
Xian F, Sondermann JR, Gomez Varela D, Schmidt M. Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice. eLife. 2022 Nov 30;11:e81431. doi: 10.7554/eLife.81431
Schmidt M, Sondermann JR, Gomez-Varela D, Çubuk C, Millet Q, Lewis MJ et al. Transcriptomic and proteomic profiling of NaV1.8-expressing mouse nociceptors. Frontiers in molecular neuroscience. 2022 Oct 11;15:1002842. doi: 10.3389/fnmol.2022.1002842
Klen R, Purohit D, Gomez-Huelgas R, Casas-Rojo JM, Anton-Santos JM, Nunez-Cortes JM et al. Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study. eLife. 2022 May 17;11:e75985. doi: 10.7554/eLife.75985
Segelcke D, Burgt MVD, Kappert C, Schmidt-Garcia D, Sondermann JR, Bigalke S et al. Species-specific cutaneous protein signatures upon incision injury and correlation with distinct pain-related phenotypes in humans. bioRxiv. 2022 Mar 8. doi: 10.1101/2022.03.07.482980
de Clauser L, Kappert C, Sondermann JR, Gomez-Varela D, Flatters SJL, Schmidt M. Proteome and Network Analysis Provides Novel Insights Into Developing and Established Chemotherapy-Induced Peripheral Neuropathy. Frontiers in Pharmacology. 2022 Feb 18;13:818690. doi: 10.3389/fphar.2022.818690