Professors
Assoz.- Prof. Mag. Dr. Anna Weinzinger, Privatdoz.
room: 2D178
tel: +43 1 4277 55311
e-mail: anna.stary@univie.ac.at
Anna Weinzinger (photo: Michael Bründl)
Publications
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Baburin I, Varkevisser R, Schramm A, Saxena P, Beyl S, Szkokan P et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are I-Kr blockers with proarrhythmic effects in vitro and in vivo. Pharmacological Research. 2018 Mai;131:150-163. doi: 10.1016/j.phrs.2018.02.024
Cervenka R, Lukacs P, Gawali VS, Ke S, Koenig X, Rubi L et al. Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures. Scientific Reports. 2018 Jan 12;8(1):631. doi: 10.1038/s41598-017-18919-1
Gualdani R, Cavalluzzi MM, Tadini-Buoninsegni F, Convertino M, Gailly P, Stary-Weinzinger A et al. Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole. Cellular Physiology and Biochemistry. 2018;45(6):2233-2245. doi: 10.1159/000488169
Cooper PE, McClenaghan C, Chen X, Stary-Weinzinger A, Nichols CG. Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. Journal of Biological Chemistry. 2017 Okt 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971
Gardner A, Wu W, Thomson S, Zangerl-Plessl E-M, Stary-Weinzinger A, Sanguinetti MC. Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3. Molecular Pharmacology. 2017 Okt;92(4):437-450. doi: 10.1124/mol.117.108886
Ji Y, Veldhuis MG, Zandvoort J, Romunde FL, Houtman MJC, Duran K et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. Journal of Biomedical Science. 2017 Jul 15;24(1):44. 44. doi: 10.1186/s12929-017-0352-x
Bernsteiner H, Bründl M, Stary-Weinzinger A. Dynamics of the EAG1 K+ channel selectivity filter assessed by molecular dynamics simulations. Biochemical and Biophysical Research Communications. 2017 Feb 26;484(1):107-112. doi: 10.1016/j.bbrc.2017.01.064
Saxena P, Zangerl-Plessl E-M, Linder T, Windisch A, Hohaus A, Timin E et al. New potential binding determinant for hERG channel inhibitors. Scientific Reports. 2016 Apr 12;6:24182. doi: 10.1038/srep24182
Linder T, Bernsteiner H, Saxena P, Bauer F, Erker T, Timin E et al. Drug trapping in hERG K+ channels: (Not) a matter of drug size? MedChemComm. 2016 Mär 1;7(3):512-518. doi: 10.1039/c5md00443h
Lee SJ, Ren F, Zangerl-Plessl E-M, Heyman S, Stary-Weinzinger A, Yuan P et al. Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids. Journal of General Physiology. 2016;148(3):227-237. doi: 10.1085/jgp.201611616
Linder T, Wang S, Plessl E-M, Nichols CG, Weinzinger A. Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels. Journal of Chemical Information and Modeling. 2015 Mär 20;55(4):814–822. doi: https://doi.org/10.1021/acs.jcim.5b00010
Linder T, Saxena P, Timin E, Hering S, Weinzinger A. Structural Insights into Trapping and Dissociation of Small Molecules in K+ Channels. Journal of Chemical Information and Modeling. 2014 Nov;54(11):3218-3228. doi: 10.1021/ci500353r
Houtman MJC, Korte M, Yi Y, Vos MA, van der Heyden MAG, Weinzinger A. Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae). Biochemical and Biophysical Research Communications. 2014 Okt 3;452(4):992-997. doi: 10.1016/j.bbrc.2014.09.031
Thurner P, Stary-Weinzinger A, Gafar H, Gawali VS, Kudlacek O, Zezula J et al. Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine. Journal of Pharmacology and Experimental Therapeutics. 2014 Feb;348(2):346-358. doi: 10.1124/jpet.113.209643
Saxena P, Linder T, Stary-Weinzinger A, IJzerman AP, Timin E, Ecker GF et al. Insights into Molecular Basis of hERG Inhibition by Studying a Library of Dofetilide Derivatives. Biophysical Journal. 2014 Jan 28;106(2):138a. doi: 10.1016/j.bpj.2013.11.806
Ke S, Timin E, Weinzinger A. Different inward and outward conduction mechanisms in NaVMs suggested by molecular dynamics simulations. PLoS Computational Biology. 2014;10(7):e1003746. doi: 10.1371/journal.pcbi.1003746
Lukacs P, Gawali V, Cervenka R, Ke S, Rubi L, Zarrabi T et al. Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics. Journal of Biological Chemistry. 2014;289(31):21770-21781. doi: 10.1074/jbc.M113.541763
Saxena P, Linder T, Weinzinger A, Timin E, Ecker GF, Hering S. Refined Molecular Model for Dofetilide-Herg Channel interaction. Indian Journal of Pharmacology. 2013 Dez;45:S32-S32.
van der Heyden MAG, Stary-Weinzinger A, Sanchez-Chapula JA. Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs. Current molecular medicine. 2013 Sep;13(8):1284-98.
Takanari H, Nalos L, Stary-Weinzinger A, de Git KCG, Varkevisser R, Linder T et al. Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue. Cardiovascular Research. 2013 Jul 1;99(1):203-214. doi: 10.1093/cvr/cvt103
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Projects
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PROSTAGLANDINES - POTENTIAL THERAPEUTICS FOR DEND SYNDROME?
1/12/20 → 30/07/23
Projekt: Forschungsförderung
Molekulare Arzneistoff-Targets
Hering, S., Ecker, G., Maulide, N., Weinzinger, A. & Gonzalez Herrero, L.
1/12/10 → 31/12/22
Projekt: Forschungsförderung
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