Manuela Schmidt
Head
Univ. Prof. Manuela Schmidt, Ph.D
room: 2D349
tel: +43-1-4277-55360
e-mail: manuela_schmidt(at)univie.ac.at
Research: Systems Biology of Pain
Teaching: more information
Funktionen
- Vizedekanin - Fakultät für Lebenswissenschaften
- stv. Leiterin - Department für Pharmazeutische Wissenschaften
Publikationen
2026
Sondermann, JR, Barry, AM, Xian, F, Haberl, T, Gomez-Varela, D, Benseler, F, Schreiner, D, Brose, N, Lipstein, N & Schmidt, M 2026, 'Proximity Labelling Reveals the Compartmental Proteome of Murine Sensory Neurons', European Journal of Pain, vol. 30, no. 5, pp. e70277. https://doi.org/10.1002/ejp.70277
Haroutounian, S, Segelcke, D, Sondermann, JR, Pradier, B, Vollert, J, Xian, F, Alaverdyan, H, Holzer, KJ, Bernstein, H, Bulenda, C, Schmidt, M & Pogatzki-Zahn, EM 2026, 'Proteome-assisted multi-feature discriminant modelling of chronic post-surgical pain in female patients: A proof-of-concept study', Pharmacological Research, vol. 227. https://doi.org/10.1016/j.phrs.2026.108175
2025
Grundtner, S, Xian, F, Malzl, D, Radits, T, Barry, AM, Sondermann, JR, Menche, J, Gómez-Varela, D & Schmidt, M 2025, 'Temporal and demographic patterns of peripheral nerve proteomes in preclinical neuropathic pain', Biomedicine & Pharmacotherapy, vol. 193, 118855. https://doi.org/10.1016/j.biopha.2025.118855
Haiss, P, Liu, R, Xian, F, Varela, DG, Schmidt, M, Dirsch, VM & Blažević, T 2025, 'Evodiamine induces centrosome amplification with subsequent G2/M cell cycle arrest in primary vascular smooth muscle cells', Biochemical Pharmacology, vol. 242, no. Pt 2, 117320. https://doi.org/10.1016/j.bcp.2025.117320
Barry, AM, Sondermann, JR, Lesnak, JB, Xian, F, Franco-Enzástiga, Ú, O’Brien, JA, Varela, DG, Schackmuth, MK, Shiers, S, Price, TJ & Schmidt, M 2025, 'Multi-omic integration with human dorsal root ganglia proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway', Pain, vol. 166, no. 10, pp. 2386-2402. https://doi.org/10.1097/j.pain.0000000000003656
Xian, F, Brenek, M, Krisp, C, Urbauer, E, Kumar, RKR, Aguanno, D, Srikumar, T, Liu, Q, Barry, AM, Ma, B, Krieger, J, Haller, D, Schmidt, M & Gómez-Varela, D 2025, 'Ultra-sensitive metaproteomics redefines the dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal diseases', Nature Communications, vol. 16, 6644. https://doi.org/10.1038/s41467-025-61977-7
Sondermann, JR, Barry, A, Xian, F, Haberl, T, Gomez Varela, D, Benseler, F, Schreiner, D, Lipstein, N, Brose, N & Schmidt, M 2025 'Proximity labelling reveals the compartmental proteome of murine sensory neurons' bioRxiv : the preprint server for biology, bioRxiv, pp. 1-53. https://doi.org/10.1101/2025.06.13.659475
Lohrberg, M, Mortensen, LS, Thomas, C, Fries, F, van der Meer, F, Götz, A, Landt, C, Rhee, HJ, Rhee, J, Gómez-Varela, D, Schmidt, M, Möbius, W, Ruhwedel, T, Pardo, LA, Remling, L, Kramann, N, Wrzos, C, Bahn, E, Stadelmann, C & Barrantes-Freer, A 2025, 'Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination', Journal of Neuroinflammation, vol. 22, no. 1, 47. https://doi.org/10.1186/s12974-025-03368-9
Segelcke, D, Sondermann, JR, Kappert, C, Padier, B, Görlich, D, Fobker, M, Vollert, J, Zahn, PK, Schmidt, M & Pogatzki-Zahn, EM 2025, 'Blood proteomics and multimodal risk profiling of human volunteers after incision injury: A translational study for advancing personalized pain management after surgery', Pharmacological Research, vol. 212, 107580. <http://10.1016/j.phrs.2025.107580>
Xian, F, Brenek, M, Krisp, C, Aguanno, D, Urbauer, E, Srikumar, T, Ravi Kumar, RK, Liu, Q, Barry, A, Ma, B, Krieger, J, Haller, D, Schmidt, M & Gomez Varela, D 2025 'Ultra-sensitivity metaproteomics redefines the gut “dark metaproteome”, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases' bioRxiv. https://doi.org/10.1101/2024.04.22.590295
Grundtner, S, Sondermann, JR, Xian, F, Malzl, D, Segelcke, D, Pogatzki-Zahn, EM, Menche, J, Gómez-Varela, D & Schmidt, M 2025, 'Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia', Pharmacological Research, vol. 211, 107552. https://doi.org/10.1016/j.phrs.2024.107552
Schmidt, M 2025, 'Systematic review and quantitative trend analysis of scientific quality in preclinical studies using rodent models of post-surgical pain', Neuroscience and Biobehavioral Reviews . https://doi.org/10.1016/j.neubiorev.2025.106422
2024
Barry, A, Price, T & Schmidt, M, Bulk Proteomics (DIA-MS) of Human Dorsal Root Ganglion v1, 2024, Web publication. https://doi.org/10.17504/protocols.io.j8nlk8j56l5r/v1
Urbauer, E, Aguanno, D, Mindermann, N, Omer, H, Metwaly, A, Krammel, T, Faro, T, Remke, M, Reitmeier, S, Bärthel, S, Kersting, J, Huang, Z, Xian, F, Schmidt, M, Saur, D, Huber, S, Stecher, B, List, M, Gómez-Varela, D, Steiger, K, Allez, M, Rath, E & Haller, D 2024, 'Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease', Cell Host & Microbe, vol. 32, no. 8, pp. 1347-1364.e10. https://doi.org/10.1016/j.chom.2024.06.013
Barry, A, Schmidt, M & Price, T, Bulk proteomics of naive human dorsal root ganglion, 2024, Software or database. https://doi.org/10.26275/z7uy-kuif
Barry, A, Sondermann, JR, Lesnak, J, Xian, F, Franco-Enzástiga, Ú, O’Brien, J, Gomez Varela, D, Schackmuth, M, Shiers, S, Price, T & Schmidt, M 2024 'Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway' bioRxiv : the preprint server for biology, bioRxiv. https://doi.org/10.1101/2024.12.06.626968
2023
Gómez-Varela, D, Xian, F, Grundtner, S, Sondermann, JR, Carta, G & Schmidt, M 2023, 'Increasing taxonomic and functional characterization of host-microbiome interactions by DIA-PASEF metaproteomics', Frontiers in Microbiology, vol. 14, 1258703. https://doi.org/10.3389/fmicb.2023.1258703
Segelcke, D, van der Burgt, M, Kappert, C, Schmidt Garcia, D, Sondermann, JR, Bigalke, S, Pradier, B, Gomez-Varela, D, Zahn, PK, Schmidt, M & Pogatzki-Zahn, EM 2023, 'Phenotype- and species-specific skin proteomic signatures for incision-induced pain in humans and mice', British Journal of Anaesthesia (BJA), vol. 130, no. 3, pp. 331-342. https://doi.org/10.1016/j.bja.2022.10.040
2022
Xian, F, Sondermann, JR, Gomez Varela, D & Schmidt, M 2022, 'Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice', eLife, vol. 11, e81431. https://doi.org/10.7554/eLife.81431
Schmidt, M, Sondermann, JR, Gomez-Varela, D, Çubuk, C, Millet, Q, Lewis, MJ, Wood, JN & Zhao, J 2022, 'Transcriptomic and proteomic profiling of NaV1.8-expressing mouse nociceptors', Frontiers in molecular neuroscience, vol. 15, 1002842. https://doi.org/10.3389/fnmol.2022.1002842