Research at the Division of Pharmacology and Toxicology is driven by the motivation to decipher the dynamic mechanisms underlying aging and disease, such as chronic pain, cerebrovascular diseases, neurodegeneration, and rare neurodevelopmental diseases. To this end, we combine a diverse set of methods ranging from biochemistry, electrophysiology, primary cell culture and preclinical mouse models to molecular modelling and quantitative proteomics. In addition to preclinical work our translational research goals benefit from valuable collaborations with clinicians and patient communities. We strive to identify novel targets that have the potential to promote healthy aging and improve the prevention as well as treatment of aforementioned diseases.