Head

 

Univ. Prof. Manuela Schmidt, Ph.D

room: 2D349

tel: +43 1 4277 55360

e-mail: manuela_schmidt@univie.ac.at

Research: Systems Biology of Pain

Teaching: more information

 

 

Funktionen

 

 

 

Manuela Schmidt (photo: Frank Stefan Kimmel)

 Publications

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Sondermann JR, Barry A, Xian F, Haberl T, Gomez Varela D, Benseler F et al. Proximity labelling reveals the compartmental proteome of murine sensory neurons. bioRxiv. 2025 Jun, S. 1-53. doi: 10.1101/2025.06.13.659475
Barry AM, Sondermann JR, Lesnak JB, Xian F, Franco-Enzástiga Ú, O’Brien JA et al. Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway. Pain. 2025 Mai 20. doi: 10.1097/j.pain.0000000000003656
Lohrberg M, Mortensen LS, Thomas C, Fries F, van der Meer F, Götz A et al. Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination. Journal of Neuroinflammation. 2025 Feb 23;22(1):47. doi: 10.1186/s12974-025-03368-9
Xian F, Brenek M, Krisp C, Aguanno D, Urbauer E, Srikumar T et al. Ultra-sensitivity metaproteomics redefines the gut “dark metaproteome”, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases. bioRxiv. 2025 Jan 10. doi: 10.1101/2024.04.22.590295
Segelcke D, Sondermann JR, Kappert C, Padier B, Görlich D, Fobker M et al. Blood proteomics and multimodal risk profiling of human volunteers after incision injury: A translational study for advancing personalized pain management after surgery. Pharmacological Research. 2025.
Grundtner S, Sondermann JR, Xian F, Malzl D, Segelcke D, Pogatzki-Zahn EM et al. Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia. Pharmacological Research. 2024 Dez;211:107552. Epub 2024 Dez 16. doi: 10.1016/j.phrs.2024.107552
Barry A, Price T, Schmidt M. Bulk Proteomics (DIA-MS) of Human Dorsal Root Ganglion v1 2024. doi: 10.17504/protocols.io.j8nlk8j56l5r/v1
Urbauer E, Aguanno D, Mindermann N, Omer H, Metwaly A, Krammel T et al. Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease. Cell Host & Microbe. 2024 Aug 14;32(8):1347-1364.e10. doi: 10.1016/j.chom.2024.06.013
Barry A, Schmidt M, Price T. Bulk proteomics of naive human dorsal root ganglion 2024. doi: 10.26275/z7uy-kuif
Barry A, Sondermann JR, Lesnak J, Xian F, Franco-Enzástiga Ú, O’Brien J et al. Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway. bioRxiv. 2024. doi: 10.1101/2024.12.06.626968
Segelcke D, van der Burgt M, Kappert C, Schmidt Garcia D, Sondermann JR, Bigalke S et al. Phenotype- and species-specific skin proteomic signatures for incision-induced pain in humans and mice. British Journal of Anaesthesia (BJA). 2023 Mär;130(3):331-342. Epub 2023 Jan 5. doi: 10.1016/j.bja.2022.10.040
Gómez-Varela D, Xian F, Grundtner S, Sondermann JR, Carta G, Schmidt M. Increasing taxonomic and functional characterization of host-microbiome interactions by DIA-PASEF metaproteomics. Frontiers in Microbiology. 2023;14:1258703. 1258703. doi: 10.3389/fmicb.2023.1258703
Xian F, Sondermann JR, Gomez Varela D, Schmidt M. Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice. eLife. 2022 Nov 30;11:e81431. doi: 10.7554/eLife.81431
Schmidt M, Sondermann JR, Gomez-Varela D, Çubuk C, Millet Q, Lewis MJ et al. Transcriptomic and proteomic profiling of NaV1.8-expressing mouse nociceptors. Frontiers in molecular neuroscience. 2022 Okt 11;(15):1002842. doi: 10.3389/fnmol.2022.1002842
Segelcke D, Burgt MVD, Kappert C, Schmidt-Garcia D, Sondermann JR, Bigalke S et al. Species-specific cutaneous protein signatures upon incision injury and correlation with distinct pain-related phenotypes in humans. bioRxiv. 2022 Mär 8. doi: 10.1101/2022.03.07.482980
de Clauser L, Kappert C, Sondermann JR, Gomez-Varela D, Flatters SJL, Schmidt M. Proteome and Network Analysis Provides Novel Insights Into Developing and Established Chemotherapy-Induced Peripheral Neuropathy. Frontiers in Pharmacology. 2022 Feb 18;(13):818690. doi: 10.3389/fphar.2022.818690
Segelcke D, Fischer HK, Hütte M, Dennerlein S, Benseler F, Brose N et al. Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice. Cell Reports. 2021 Dez 21;37(12):110152. doi: 10.1016/j.celrep.2021.110152
Zhu S, Stanslowsky N, Fernández-Trillo J, Mamo TM, Yu P, Kalmbach N et al. Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2. stem cell research. 2021 Okt;56:102535. doi: 10.1016/j.scr.2021.102535
Pogatzki-Zahn EM, Gomez-Varela D, Erdmann G, Kaschube K, Segelcke D, Schmidt M. A proteome signature for acute incisional pain in dorsal root ganglia of mice. Pain. 2021 Jul;162(7):2070-2086. doi: 10.1097/j.pain.0000000000002207
Michel N, Narayanan P, Shomroni O, Schmidt M. Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction. Cell Reports. 2020 Jul 21;32(3):107912. doi: 10.1016/j.celrep.2020.107912
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