Post docs

Dr. Eva-Maria Plessl, BSc. MSc.

room: 2E153

tel: +43 1 4277 55321

e-mail: eva-maria.zangerl@univie.ac.at

more information

Publications

Maksaev G, Bründl-Jirout M, Stary-Weinzinger A , Zangerl-Plessl EM, Lee SJ, Nichols CG. Subunit gating resulting from individual protonation events in Kir2 channels. Nature Communications. 2023 Jul 28;14(1):4538. 4538. doi: 10.1038/s41467-023-40058-7

Plessl EM, Wu W, Sanguinetti MC, Weinzinger A. Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate. Frontiers in Molecular Biosciences. 2023;10:1137368. doi: 10.3389/fmolb.2023.1137368

Weinzinger A , Plessl EM. Special Issue "Potassium Channels as Novel Therapeutic Targets". 2023. (Pharmaceuticals).

Garifulina A, Friesacher T, Stadler M, Zangerl-Plessl EM, Ernst M, Stary-Weinzinger A et al. β subunits of GABA_A receptors form proton-gated chloride channels: Insights into the molecular basis. Communications Biology. 2022 Aug 3;5(1):784. doi: 10.1038/s42003-022-03720-2

Plessl EM, Lee SJ, Maksaev G, Bernsteiner H, Ren F, Yuan P et al. Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels. Journal of General Physiology. 2020 Jan;152(1):e201912422. doi: 10.1085/jgp.201912422, 10.1085/jgp.201912422

Plessl EM, Berger M, Drescher M, Chen Y, Wu W, Maulide N et al. Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574. Journal of Chemical Information and Modeling. 2020 Jan;60(1):360-371. doi: 10.1021/acs.jcim.9b00737

Plessl EM, Qile M, Bloothooft M, Weinzinger A, van der Heyden M. Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking. Biomolecules. 2019 Nov;9(11):650. doi: 10.3390/biom9110650

Bernsteiner H, Plessl EM, Chen X, Weinzinger A. Conduction through a narrow inward-rectifier K+ channel pore. Journal of General Physiology. 2019 Sep.

Chen X, Garon A, Wieder M, Houtman MJC, Zangerl-Plessl EM , Langer T et al. Computational identification of novel Kir6 channel inhibitors. Frontiers in Pharmacology. 2019 Mai;10:549. doi: 10.3389/fphar.2019.00549

Plessl EM, van der Heyden MAG. Commentary: Golgin-97 Targets Ectopically Expressed Inward Rectifying Potassium Channel, Kir2.1, to the Trans-Golgi Network in COS-7 Cells. Frontiers in Psychology. 2018 Okt 5;9:1401. doi: 10.3389/fphys.2018.01401

Hering S, Plessl EM, Beyl S, Hohaus A, Andranovits S, Timin E. Calcium channel gating. Pflügers Archiv: European Journal of Physiology. 2018 Sep;470(9):1291-1309. 470. doi: 10.1007/s00424-018-2163-7

Andranovits S, Beyl S, Hohaus A, Zangerl-Plessl EM, Timin E, Hering S. Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation. Pflügers Archiv: European Journal of Physiology. 2017 Nov;469(11):1485–1493. Epub 2017 Aug 1. doi: 10.1007/s00424-017-2038-3

Gardner A, Wu W, Thomson S, Zangerl-Plessl EM , Stary-Weinzinger A, Sanguinetti MC. Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3. Molecular Pharmacology. 2017 Okt;92(4):437-450. doi: 10.1124/mol.117.108886

Ji Y, Veldhuis MG, Zandvoort J, Romunde FL, Houtman MJC, Duran K et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. Journal of Biomedical Science. 2017 Jul 15;24(1):44. 44. doi: 10.1186/s12929-017-0352-x

Saxena P, Zangerl-Plessl EM, Linder T, Windisch A, Hohaus A, Timin E et al. New potential binding determinant for hERG channel inhibitors. Scientific Reports. 2016 Apr 12;6:24182. doi: 10.1038/srep24182

Lee SJ, Ren F, Zangerl-Plessl EM, Heyman S, Stary-Weinzinger A, Yuan P et al. Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids. Journal of General Physiology. 2016;148(3):227-237. doi: 10.1085/jgp.201611616

Linder T, Wang S, Plessl EM, Nichols CG, Weinzinger A. Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels. Journal of Chemical Information and Modeling. 2015 Mär 20;55(4):814–822. doi: 10.1021/acs.jcim.5b00010

Ke S, Zangerl EM , Weinzinger A. Distinct interactions of Na(+) and Ca(2+) ions with the selectivity filter of the bacterial sodium channel Na(V)Ab. Biochemical and Biophysical Research Communications. 2012;430(4):1272-1276. doi: 10.1016/j.bbrc.2012.12.055