Senior Scientist

Dr. David Gomez Varela

room: 2D351

tel: +43 1 4277 55361

e-mail: david.gomez.varela@univie.ac.at

Personal Homepage: https://homepage.univie.ac.at/david.gomez.varela/

Director of the Center of Excellence for Metaproteomics

David Gomez Varela (photo: MPIem)

Publications

Sondermann JR, Barry A , Xian F, Haberl T, Gomez Varela D, Benseler F et al. Proximity labelling reveals the compartmental proteome of murine sensory neurons. bioRxiv. 2025 Jun, S. 1-53. doi: 10.1101/2025.06.13.659475

Barry AM, Sondermann JR, Lesnak JB, Xian F, Franco-Enzástiga Ú, O’Brien JA et al. Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway. Pain. 2025 Mai 20. doi: 10.1097/j.pain.0000000000003656

Lohrberg M, Mortensen LS, Thomas C, Fries F, van der Meer F, Götz A et al. Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination. Journal of Neuroinflammation. 2025 Feb 23;22(1):47. doi: 10.1186/s12974-025-03368-9

Xian F, Brenek M, Krisp C, Aguanno D, Urbauer E, Srikumar T et al. Ultra-sensitivity metaproteomics redefines the gut “dark metaproteome”, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases. bioRxiv. 2025 Jan 10. doi: 10.1101/2024.04.22.590295

Grundtner S, Sondermann JR, Xian F , Malzl D, Segelcke D, Pogatzki-Zahn EM et al. Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia. Pharmacological Research. 2024 Dez;211:107552. Epub 2024 Dez 16. doi: 10.1016/j.phrs.2024.107552

Urbauer E, Aguanno D, Mindermann N, Omer H, Metwaly A, Krammel T et al. Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease. Cell Host & Microbe. 2024 Aug 14;32(8):1347-1364.e10. doi: 10.1016/j.chom.2024.06.013

Barry A, Sondermann JR, Lesnak J, Xian F, Franco-Enzástiga Ú, O’Brien J et al. Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway. bioRxiv. 2024. doi: 10.1101/2024.12.06.626968

Klén R, Huespe IA, Gregalio FA, Lalueza Blanco AL, Pedrera Jimenez M, Garcia Barrio N et al. Development and validation of COEWS (COVID-19 Early Warning Score) for hospitalized COVID-19 with laboratory features: A multicontinental retrospective study. eLife. 2023 Aug 24;12:e85618. doi: 10.7554/eLife.85618

Huespe IA, Ferraris A, Lalueza A, Valdez PR, Peroni ML, Cayetti LA et al. COVID-19 vaccines reduce mortality in hospitalized patients with oxygen requirements: Differences between vaccine subtypes. A multicontinental cohort study. Journal of medical virology. 2023 Mai 15;95(5):e28786. doi: 10.1002/jmv.28786

Segelcke D, van der Burgt M, Kappert C, Schmidt Garcia D, Sondermann JR, Bigalke S et al. Phenotype- and species-specific skin proteomic signatures for incision-induced pain in humans and mice. British Journal of Anaesthesia (BJA). 2023 Mär;130(3):331-342. Epub 2023 Jan 5. doi: 10.1016/j.bja.2022.10.040

Gómez-Varela D , Xian F, Grundtner S, Sondermann JR, Carta G , Schmidt M. Increasing taxonomic and functional characterization of host-microbiome interactions by DIA-PASEF metaproteomics. Frontiers in Microbiology. 2023;14:1258703. 1258703. doi: 10.3389/fmicb.2023.1258703

Xian F, Sondermann JR, Gomez Varela D , Schmidt M. Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice. eLife. 2022 Nov 30;11:e81431. doi: 10.7554/eLife.81431

Schmidt M, Sondermann JR, Gomez-Varela D, Çubuk C, Millet Q, Lewis MJ et al. Transcriptomic and proteomic profiling of NaV1.8-expressing mouse nociceptors. Frontiers in molecular neuroscience. 2022 Okt 11;(15):1002842. doi: 10.3389/fnmol.2022.1002842

Klen R, Purohit D, Gomez-Huelgas R, Casas-Rojo JM, Anton-Santos JM, Nunez-Cortes JM et al. Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study. eLife. 2022 Mai 17;11:e75985. doi: 10.7554/eLife.75985

Segelcke D, Burgt MVD, Kappert C, Schmidt-Garcia D, Sondermann JR, Bigalke S et al. Species-specific cutaneous protein signatures upon incision injury and correlation with distinct pain-related phenotypes in humans. bioRxiv. 2022 Mär 8. doi: 10.1101/2022.03.07.482980

de Clauser L, Kappert C, Sondermann JR, Gomez-Varela D, Flatters SJL, Schmidt M. Proteome and Network Analysis Provides Novel Insights Into Developing and Established Chemotherapy-Induced Peripheral Neuropathy. Frontiers in Pharmacology. 2022 Feb 18;(13):818690. doi: 10.3389/fphar.2022.818690

Pogatzki-Zahn EM, Gomez-Varela D, Erdmann G, Kaschube K, Segelcke D, Schmidt M. A proteome signature for acute incisional pain in dorsal root ganglia of mice. Pain. 2021 Jul;162(7):2070-2086. doi: 10.1097/j.pain.0000000000002207

Gomez-Varela D , Barry AM , Schmidt M. Proteome-based systems biology in chronic pain. Journal of Proteomics. 2019. doi: 10.1016/j.jprot.2018.04.004

Sondermann JR, Barry AM, Jahn O, Michel N, Abdelaziz R, Kügler S et al. Vti1b promotes TRPV1 sensitization during inflammatory pain. Pain. 2019. doi: 10.1097/j.pain.0000000000001418

Narayanan P, Hütte M, Kudryasheva G, Taberner FJ, Lechner SG, Rehfeldt F et al. Myotubularin related protein-2 and its phospholipid substrate PIP <inf>2</inf> control Piezo2-mediated mechanotransduction in peripheral sensory neurons. eLife. 2018;7:e26280. doi: 10.7554/eLife.32346