Post docs
Dipl.-Ing. (FH) Mag. Dr. Annette Hohaus
Raum: 2D347
Tel: +43 1 4277 55308
Publikationen
Hering S, Plessl E-M, Beyl S, Hohaus A, Andranovits S, Timin E. Calcium channel gating. Pflügers Archiv: European Journal of Physiology. 2018 Jun 27;470:1291-1309. 470. doi.org/10.1007/s00424-018-2163-7
Hering S, Plessl E-M, Beyl S, Hohaus A, Andranovits S, Timin E. On the molecular base of CaV1.2 gating. 2018.
Andranovits S, Beyl S, Hohaus A, Zangerl-Plessl EM, Timin E, Hering S. Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation. Pflügers Archiv: European Journal of Physiology. 2017 Nov;469(11):1485–1493. doi.org/10.1007/s00424-017-2038-3
Saxena P, Zangerl-Plessl E-M, Linder T, Windisch A, Hohaus A, Timin E et al. New potential binding determinant for hERG channel inhibitors. Scientific Reports. 2016 Apr 12;6. 24182. doi.org/10.1038/srep24182
Beyl S, Hohaus A, Andranovits S, Timin E, Hering S. Upward movement of IS4 and IIIS4 is a rate-limiting stage in Cav1.2 activation. Pflügers Archiv: European Journal of Physiology. 2016 Nov;468(11-12):1895-1907. doi.org/10.1007/s00424-016-1895-5
Luger D, Ke S, Ernst M, Hohaus A, Seidel T, Langer T et al. A potential binding site for valerenic acid on GABAA receptors. 2015.
Luger D, Poli G, Wieder M, Stadler MJ, Ke S, Ernst M et al. Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis. British Journal of Pharmacology. 2015 Okt 25;172(22).
Beyl S, Kügler P, Hohaus A, Depil K, Hering S, Timin E. Methods for quantification of pore-voltage sensor interaction in CaV1.2. Pflügers Archiv: European Journal of Physiology. 2014;265-74. doi.org/10.1007/s00424-013-1319-8
Beyl S, Depil K, Hohaus A, Weinzinger A, Linder T, Timin E et al. Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of Ca(V)1.2: a cooperative gating model. Pflügers Archiv: European Journal of Physiology. 2012 Okt;464(4):391-401. doi.org/10.1007/s00424-012-1144-5
Shabbir W, Beyl S, Timin E, Schellmann D, Erker T, Hohaus A et al. Interaction of diltiazem with an intracellularly accessible binding site on Ca(V)1.2. British Journal of Pharmacology. 2011;162(5):1074-1082. doi.org/10.1111/j.1476-5381.2010.01091.x
Beyl S, Depil K, Hohaus A, Weinzinger A, Timin E, Shabbir W et al. Physicochemical properties of pore residues predict activation gating of Ca(V)1.2: A correlation mutation analysis. Pflügers Archiv: European Journal of Physiology. 2011;461(1):53-63. doi.org/10.1007/s00424-010-0885-2
Depil K, Beyl S, Weinzinger A, Hohaus A, Timin E, Hering S. Timothy mutation disrupts the link between activation and inactivation in Ca(V)1.2 protein. Journal of Biological Chemistry. 2011;286(36):31557-31564. doi.org/10.1074/jbc.M111.255273
Beyl S, Hohaus A, Depil K, Weinzinger A, Timin E, Hering S. Activation gating determinants in Segments IS6-IIIS6 of Cav1.2. 2010. Postersitzung präsentiert bei Biophysical Society 54th Annual Meeting, San Francisco, California, USA / Vereinigte Staaten.
Shabbir W, Timin E, Schellmann D, Erker T, Hohaus A, Hockerman G et al. Interaction of diltiazem with an intracellularly accessible binding site on CaV1.2: Interaction of diltiazem with an intracellularly accessible binding site on CaV1.2. 2010. Postersitzung präsentiert bei Ion Channel Symposium, Österreich.
Kudrnac M, Beyl S, Hohaus A, Weinzinger A, Peterbauer T, Timin E et al. Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2. Journal of Biological Chemistry. 2009;284(18):12276-12284.
Beyl S, Kügler P, Kudrnac M, Hohaus A, Hering S, Timin E. Different pathways for activation and deactivation in CaV1.2: a minimal gating model. Journal of General Physiology. 2009;134(3):231-241.
Windisch A, Schiesaro A, Thai KM, Timin E, Hohaus A, Ecker G et al. Ligand determinants of drug trapping in hERG potassium channels. 2009. Postersitzung präsentiert bei 21. Wissenschaftliche Tagung der Österreichischen Pharmazeutischen Gesellschaft, Wien, Österreich.
Baburin I, Khom S, Timin E, Hohaus A, Sieghart W, Hering S. Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits. Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits. British Journal of Pharmacology. 2008;155(3):424-433. doi.org/10.1038/bjp.2008.271
Weinzinger A, Kudrnac M, Beyl S, Hohaus A, Timin E, Wolschann KP et al. Molecular dynamics and mutational analysis of a channelopathy mutation in the IIS6 helix of Ca(V)1.2. Channels (Austin). 2008;2(3):116-223. doi.org/10.4161/chan.2.3.6160
Hering S, Beyl S, Weinzinger A, Kudrnac M, Hohaus A, Guy HR et al. Pore stability and gating in voltage-activated calcium channels. Channels (Austin). 2008;2:61-69. doi.org/10.4161/chan.2.2.5999