Professors

Assoz.- Prof. Mag. Dr. Anna Weinzinger, Privatdoz.

room: 2D178

tel: +43 1 4277 55311

Research: Molecular modeling of ion channels

Publications

Shalomov B, Friesacher T, Yakubovic D, Carlo Combista J, Reddy HP, Dabbah S et al. Ethosuximide: Subunit- and Gβγ-dependent blocker and reporter of allosteric changes in GIRK channels. British Journal of Pharmacology. 2025 Apr;182(8):1704-1718. Epub 2025 Jan 15. doi: 10.1111/bph.17446

Zangerl-Plessl EM, Weinzinger A, Nichols C, Lee S. PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating. Journal of General Physiology. 2025.

Sauer J, Marksteiner J, Hohenegger M, Todt H, Kubista H, Dostal C et al. The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels. American Journal of Physiology. Heart and Circulatory Physiology. 2025.

Li E, Boujeddaine N, Houtman MJC, Maas RGC, Sluijter JPG, Ecker GF et al. Development of new Kir2.1 channel openers from propafenone analogues. British Journal of Pharmacology. 2024 Okt 17;182(3):633-650. doi: 10.1111/bph.17377

Weinzinger A. In silico models of the macromolecular NaV1.5-KIR2.1 complex. Frontiers in Physiology. 2024 Feb;15:1362964. doi: 10.3389/fphys.2024.1362964

Maksaev G, Bründl-Jirout M, Stary-Weinzinger A, Zangerl-Plessl EM, Lee SJ, Nichols CG. Subunit gating resulting from individual protonation events in Kir2 channels. Nature Communications. 2023 Jul 28;14(1):4538. 4538. doi: 10.1038/s41467-023-40058-7

Plessl EM, Wu W, Sanguinetti MC, Weinzinger A. Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate. Frontiers in Molecular Biosciences. 2023;10:1137368. doi: 10.3389/fmolb.2023.1137368

Weinzinger A, Plessl EM. Special Issue "Potassium Channels as Novel Therapeutic Targets". 2023. (Pharmaceuticals).

Garifulina A, Friesacher T, Stadler M, Zangerl-Plessl EM, Ernst M, Stary-Weinzinger A et al. β subunits of GABA_A receptors form proton-gated chloride channels: Insights into the molecular basis. Communications Biology. 2022 Aug 3;5(1):784. doi: 10.1038/s42003-022-03720-2

Hackl B, Lukacs P, Ebner J, Pesti K, Haechl N, Földi MC et al. The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels. Frontiers in Pharmacology. 2022 Mai 2;13:809802. doi: 10.3389/fphar.2022.809802

Friesacher T, Reddy HP, Bernsteiner H, Carlo Combista J, Shalomov B, Bera AK et al. A selectivity filter mutation provides insights into gating regulation of a K⁺ channel. Communications Biology. 2022 Apr 11;5(1):345. doi: 10.1038/s42003-022-03303-1

Weinzinger A. Development of I<sub>KATP</sub> Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant K<sub>IR</sub>6.2 Based Channels for Treating DEND Syndrome. Frontiers in Pharmacology. 2022 Jan 14;12:814066. doi: 10.3389/fphar.2021.814066

Bründl M, Pellikan S, Weinzinger A. Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels. Frontiers in Molecular Biosciences. 2021 Aug 10;8:711975. doi: 10.3389/fmolb.2021.711975

Qile M, Golden TD, Houtman MJC, Weinzinger A, van der Heyden MAG, van Ham W et al. LUF7244 plus dofetilide rescues aberrant Kv11.1 trafficking and produces functional IKv11.1. Molecular Pharmacology. 2020 Jun;97(6):355-364. doi: 10.1124/mol.119.118190

Chen X, Bründl M, Friesacher T, Weinzinger A. Computational Insights Into Voltage Dependence of Polyamine Block in a Strong Inwardly Rectifying K + Channel. Frontiers in Pharmacology. 2020 Mai 15;11:721. doi: 10.3389/fphar.2020.00721

Plessl EM, Lee SJ, Maksaev G, Bernsteiner H, Ren F, Yuan P et al. Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels. Journal of General Physiology. 2020 Jan;152(1):e201912422. doi: 10.1085/jgp.201912422, 10.1085/jgp.201912422

Plessl EM, Berger M, Drescher M, Chen Y, Wu W, Maulide N et al. Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574. Journal of Chemical Information and Modeling. 2020 Jan;60(1):360-371. doi: 10.1021/acs.jcim.9b00737

Plessl EM, Qile M, Bloothooft M, Weinzinger A, van der Heyden M. Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking. Biomolecules. 2019 Nov;9(11):650. doi: 10.3390/biom9110650

Qile M, Beekman HDM, Sprenkeler DJ, Houtman MJC, van Ham W, Weinzinger A et al. LUF7244, an allosteric modulator/activator of K(v)11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model. British Journal of Pharmacology. 2019 Okt 8;176(19):3871-3885. doi: 10.1111/bph.14798

Bernsteiner H, Plessl EM, Chen X, Weinzinger A. Conduction through a narrow inward-rectifier K+ channel pore. Journal of General Physiology. 2019 Sep.

Projects

Novel approaches to investigate the regulation of G-protein coupled inward rectifier K+ channels by Gβγ

Weinzinger, A. (Projektleiter*in) & Friesacher, T. (Co-Projektleiter*in)

1/08/21 → 31/07/24

Projekt: Forschungsförderung

PROSTAGLANDINES - POTENTIAL THERAPEUTICS FOR DEND SYNDROME?

Weinzinger, A. (Projektleiter*in)

1/12/20 → 30/07/23

Projekt: Forschungsförderung

Sulfonylharnstoffe

Weinzinger, A. (Projektleiter*in)

1/03/15 → 28/02/19

Projekt: Forschungsförderung

hERG K+ Channel activators

Weinzinger, A. (Projektleiter*in)

4/11/14 → 4/11/15

Projekt: Forschungsförderung

hEAG1 channel blockers

Weinzinger, A. (Projektleiter*in)

15/03/14 → 14/03/15

Projekt: Forschungsförderung

Molekulare Arzneistoff-Targets

Hering, S. (Projektleiter*in), Ecker, G. (Co-Projektleiter*in), Maulide, N. (Co-Projektleiter*in), Weinzinger, A. (Co-Projektleiter*in) & Gonzalez Herrero, L. (Co-Projektleiter*in)

1/12/10 → 31/12/22

Projekt: Forschungsförderung

hERG potassium channel

Weinzinger, A. (Projektleiter*in)

27/10/10 → 31/12/11

Projekt: Forschungsförderung