Professors

Assoz.- Prof. Mag. Dr. Anna Weinzinger, Privatdoz.

room: 2D178

tel: +43 1 4277 55311

e-mail: anna.stary@univie.ac.at

Research: Molecular modeling of ion channels

Teaching: more information

Anna Weinzinger (photo: Michael Bründl)

Publications

Weinzinger A. In silico models of the macromolecular NaV1.5-KIR2.1 complex. Frontiers in Physiology. 2024 Feb;15:1362964. doi: 10.3389/fphys.2024.1362964

Maksaev G, Bründl-Jirout M, Stary-Weinzinger A , Zangerl-Plessl E-M, Lee S-J, Nichols CG. Subunit gating resulting from individual protonation events in Kir2 channels. Nature Communications. 2023 Jul 28;14(1):4538. 4538. doi: 10.1038/s41467-023-40058-7

Plessl E-M, Wu W, Sanguinetti MC, Weinzinger A. Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate. Frontiers in Molecular Biosciences. 2023;10:1137368. doi: 10.3389/fmolb.2023.1137368

Weinzinger A , Plessl E-M. Special Issue "Potassium Channels as Novel Therapeutic Targets". 2023. (Pharmaceuticals).

Garifulina A, Friesacher T, Stadler M, Zangerl-Plessl EM, Ernst M, Stary-Weinzinger A et al. β subunits of GABA_A receptors form proton-gated chloride channels: Insights into the molecular basis. Communications Biology. 2022 Aug 3;5(1):784. doi: 10.1038/s42003-022-03720-2

Hackl B, Lukacs P, Ebner J, Pesti K, Haechl N, Földi MC et al. The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels. Frontiers in Pharmacology. 2022 Mai 2;13:809802. doi: 10.3389/fphar.2022.809802

Friesacher T, Reddy HP, Bernsteiner H, Carlo Combista J, Shalomov B, Bera AK et al. A selectivity filter mutation provides insights into gating regulation of a K⁺ channel. Communications Biology. 2022 Apr 11;5(1):345. doi: 10.1038/s42003-022-03303-1

Weinzinger A. Development of I<sub>KATP</sub> Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant K<sub>IR</sub>6.2 Based Channels for Treating DEND Syndrome. Frontiers in Pharmacology. 2022 Jan 14;12:814066. doi: 10.3389/fphar.2021.814066

Bründl M, Pellikan S, Weinzinger A. Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels. Frontiers in Molecular Biosciences. 2021 Aug 10;8:711975. doi: 10.3389/fmolb.2021.711975

Qile M, Golden TD, Houtman MJC, Weinzinger A, van der Heyden MAG, van Ham W et al. LUF7244 plus dofetilide rescues aberrant Kv11.1 trafficking and produces functional IKv11.1. Molecular Pharmacology. 2020 Jun;97(6):355-364. doi: 10.1124/mol.119.118190

Chen X, Bründl M, Friesacher T, Weinzinger A. Computational Insights Into Voltage Dependence of Polyamine Block in a Strong Inwardly Rectifying K + Channel. Frontiers in Pharmacology. 2020 Mai 15;11:721. doi: 10.3389/fphar.2020.00721

Plessl E-M, Lee SJ, Maksaev G, Bernsteiner H, Ren F, Yuan P et al. Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels. Journal of General Physiology. 2020 Jan;152(1):e201912422. doi: 10.1085/jgp.201912422, 10.1085/jgp.201912422

Plessl E-M, Berger M, Drescher M, Chen Y, Wu W, Maulide N et al. Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574. Journal of Chemical Information and Modeling. 2020 Jan;60(1):360-371. doi: 10.1021/acs.jcim.9b00737

Plessl E-M, Qile M, Bloothooft M, Weinzinger A, van der Heyden M. Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking. Biomolecules. 2019 Nov;9(11):650. doi: 10.3390/biom9110650

Qile M, Beekman HDM, Sprenkeler DJ, Houtman MJC, van Ham W, Weinzinger A et al. LUF7244, an allosteric modulator/activator of K(v)11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model. British Journal of Pharmacology. 2019 Okt 8;176(19):3871-3885. doi: 10.1111/bph.14798

Bernsteiner H, Plessl E-M, Chen X, Weinzinger A. Conduction through a narrow inward-rectifier K+ channel pore. Journal of General Physiology. 2019 Sep.

Weinzinger A. Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents. Journal of Cellular and Molecular Medicine. 2019 Aug;23(8):4962-4969. doi: 10.1111/jcmm.14329

Weinzinger A. Histidine at position 462 determines the low quinine sensitivity of ether-à-go-go (Eag) channel superfamily member Kv 12.1. British Journal of Pharmacology. 2019 Aug;176(15):2708-2723. doi: 10.1111/bph.14693

Hellsberg E, Ecker G , Weinzinger A, Forrest LR. A structural model of the human serotonin transporter in an outward-occluded state. PLoS ONE. 2019 Jun 28;14(6):e0217377. doi: 10.1371/journal.pone.0217377

Chen X, Garon A, Wieder M, Houtman MJC, Zangerl-Plessl EM , Langer T et al. Computational identification of novel Kir6 channel inhibitors. Frontiers in Pharmacology. 2019 Mai;10:549. doi: 10.3389/fphar.2019.00549

Projects

PROSTAGLANDINES - POTENTIAL THERAPEUTICS FOR DEND SYNDROME?

1/12/20 → 30/07/23

Projekt: Forschungsförderung

Sulfonylharnstoffe

1/03/15 → 28/02/19

Projekt: Forschungsförderung

hERG K+ Channel activators

4/11/14 → 4/11/15

Projekt: Forschungsförderung

Molekulare Arzneistoff-Targets

Hering, S., Ecker, G., Maulide, N., Weinzinger, A. & Gonzalez Herrero, L.

1/12/10 → 31/12/22

Projekt: Forschungsförderung