Professors

 

Assoz.- Prof. Mag. Dr. Anna Weinzinger, Privatdoz.

room: 2D178

tel: +43 1 4277 55311

e-mail: anna.stary@univie.ac.at

Research: Molecular modeling of ion channels

Teaching: more information

Anna Weinzinger (photo: Michael Bründl)

 Publications

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Weinzinger A. Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents. Journal of Cellular and Molecular Medicine. 2019 Aug;23(8):4962-4969. doi: 10.1111/jcmm.14329
Weinzinger A. Histidine at position 462 determines the low quinine sensitivity of ether-à-go-go (Eag) channel superfamily member Kv 12.1. British Journal of Pharmacology. 2019 Aug;176(15):2708-2723. doi: 10.1111/bph.14693
Hellsberg E, Ecker G, Weinzinger A, Forrest LR. A structural model of the human serotonin transporter in an outward-occluded state. PLoS ONE. 2019 Jun 28;14(6):e0217377. doi: 10.1371/journal.pone.0217377
Chen X, Garon A, Wieder M, Houtman MJC, Zangerl-Plessl EM, Langer T et al. Computational identification of novel Kir6 channel inhibitors. Frontiers in Pharmacology. 2019 Mai;10:549. doi: 10.3389/fphar.2019.00549
Baburin I, Varkevisser R, Schramm A, Saxena P, Beyl S, Szkokan P et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are I-Kr blockers with proarrhythmic effects in vitro and in vivo. Pharmacological Research. 2018 Mai;131:150-163. doi: 10.1016/j.phrs.2018.02.024
Cervenka R, Lukacs P, Gawali VS, Ke S, Koenig X, Rubi L et al. Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures. Scientific Reports. 2018 Jan 12;8(1):631. doi: 10.1038/s41598-017-18919-1
Gualdani R, Cavalluzzi MM, Tadini-Buoninsegni F, Convertino M, Gailly P, Stary-Weinzinger A et al. Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole. Cellular Physiology and Biochemistry. 2018;45(6):2233-2245. doi: 10.1159/000488169
Cooper PE, McClenaghan C, Chen X, Stary-Weinzinger A, Nichols CG. Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. Journal of Biological Chemistry. 2017 Okt 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971
Gardner A, Wu W, Thomson S, Zangerl-Plessl EM, Stary-Weinzinger A, Sanguinetti MC. Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3. Molecular Pharmacology. 2017 Okt;92(4):437-450. doi: 10.1124/mol.117.108886
Ji Y, Veldhuis MG, Zandvoort J, Romunde FL, Houtman MJC, Duran K et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. Journal of Biomedical Science. 2017 Jul 15;24(1):44. 44. doi: 10.1186/s12929-017-0352-x
Bernsteiner H, Bründl M, Stary-Weinzinger A. Dynamics of the EAG1 K+ channel selectivity filter assessed by molecular dynamics simulations. Biochemical and Biophysical Research Communications. 2017 Feb 26;484(1):107-112. doi: 10.1016/j.bbrc.2017.01.064
Saxena P, Zangerl-Plessl EM, Linder T, Windisch A, Hohaus A, Timin E et al. New potential binding determinant for hERG channel inhibitors. Scientific Reports. 2016 Apr 12;6:24182. doi: 10.1038/srep24182
Linder T, Bernsteiner H, Saxena P, Bauer F, Erker T, Timin E et al. Drug trapping in hERG K+ channels: (Not) a matter of drug size? MedChemComm. 2016 Mär 1;7(3):512-518. doi: 10.1039/c5md00443h
Lee SJ, Ren F, Zangerl-Plessl EM, Heyman S, Stary-Weinzinger A, Yuan P et al. Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids. Journal of General Physiology. 2016;148(3):227-237. doi: 10.1085/jgp.201611616
Linder T, Wang S, Plessl EM, Nichols CG, Weinzinger A. Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels. Journal of Chemical Information and Modeling. 2015 Mär 20;55(4):814–822. doi: 10.1021/acs.jcim.5b00010
Linder T, Saxena P, Timin E, Hering S, Weinzinger A. Structural Insights into Trapping and Dissociation of Small Molecules in K+ Channels. Journal of Chemical Information and Modeling. 2014 Nov;54(11):3218-3228. doi: 10.1021/ci500353r
Houtman MJC, Korte M, Yi Y, Vos MA, van der Heyden MAG, Weinzinger A. Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae). Biochemical and Biophysical Research Communications. 2014 Okt 3;452(4):992-997. doi: 10.1016/j.bbrc.2014.09.031
Thurner P, Stary-Weinzinger A, Gafar H, Gawali VS, Kudlacek O, Zezula J et al. Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine. Journal of Pharmacology and Experimental Therapeutics. 2014 Feb;348(2):346-358. doi: 10.1124/jpet.113.209643
Saxena P, Linder T, Stary-Weinzinger A, IJzerman AP, Timin E, Ecker GF et al. Insights into Molecular Basis of hERG Inhibition by Studying a Library of Dofetilide Derivatives. Biophysical Journal. 2014 Jan 28;106(2):138a. doi: 10.1016/j.bpj.2013.11.806
Ke S, Timin E, Weinzinger A. Different inward and outward conduction mechanisms in NaVMs suggested by molecular dynamics simulations. PLoS Computational Biology. 2014;10(7):e1003746. doi: 10.1371/journal.pcbi.1003746
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 Projects

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Novel approaches to investigate the regulation of G-protein coupled inward rectifier K+ channels by Gβγ

Weinzinger, A. (Projektleiter*in) & Friesacher, T. (Co-Projektleiter*in)

1/08/21 → 31/07/24

Projekt: Forschungsförderung

PROSTAGLANDINES - POTENTIAL THERAPEUTICS FOR DEND SYNDROME?

Weinzinger, A. (Projektleiter*in)

1/12/20 → 30/07/23

Projekt: Forschungsförderung

Sulfonylharnstoffe

Weinzinger, A. (Projektleiter*in)

1/03/15 → 28/02/19

Projekt: Forschungsförderung

hERG K+ Channel activators

Weinzinger, A. (Projektleiter*in)

4/11/14 → 4/11/15

Projekt: Forschungsförderung

hEAG1 channel blockers

Weinzinger, A. (Projektleiter*in)

15/03/14 → 14/03/15

Projekt: Forschungsförderung

Molekulare Arzneistoff-Targets

Hering, S. (Projektleiter*in), Ecker, G. (Co-Projektleiter*in), Maulide, N. (Co-Projektleiter*in), Weinzinger, A. (Co-Projektleiter*in) & Gonzalez Herrero, L. (Co-Projektleiter*in)

1/12/10 → 31/12/22

Projekt: Forschungsförderung

hERG potassium channel

Weinzinger, A. (Projektleiter*in)

27/10/10 → 31/12/11

Projekt: Forschungsförderung

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