Professors
Assoz.- Prof. Mag. Dr. Anna Weinzinger, Privatdoz.
room: 2D178
tel: +43 1 4277 55311
e-mail: anna.stary@univie.ac.at
Research: Molecular modeling of ion channels
Teaching: more information
Anna Weinzinger (photo: Michael Bründl)
Publications
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Lukacs P, Gawali V, Cervenka R, Ke S, Rubi L, Zarrabi T et al. Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics. Journal of Biological Chemistry. 2014;289(31):21770-21781. doi: 10.1074/jbc.M113.541763
Saxena P, Linder T, Weinzinger A, Timin E, Ecker GF, Hering S. Refined Molecular Model for Dofetilide-Herg Channel interaction. Indian Journal of Pharmacology. 2013 Dez;45:S32-S32.
van der Heyden MAG, Stary-Weinzinger A, Sanchez-Chapula JA. Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs. Current molecular medicine. 2013 Sep;13(8):1284-98.
Takanari H, Nalos L, Stary-Weinzinger A, de Git KCG, Varkevisser R, Linder T et al. Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue. Cardiovascular Research. 2013 Jul 1;99(1):203-214. doi: 10.1093/cvr/cvt103
Varkevisser R, Houtman MJC, Linder T, de Git KCG, Beekman HDM, Tidwell RR et al. Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue. British Journal of Pharmacology. 2013 Jul;169(6):1322-1334. doi: 10.1111/bph.12208
Garg V, Stary-Weinzinger A, Sanguinetti MC. ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels. Molecular Pharmacology. 2013 Apr;83(4):805-813. doi: 10.1124/mol.112.084384
Saxena P, Erker T, Bauer F, Weinzinger A, Linder T, Hering S et al. Drug Trapping in hERG Channels does not Require Closure of the Activation Gate. Biophysical Journal. 2013 Jan 29;104(2):266A-266A.
Linder T, de Groot BL, Stary-Weinzinger A. Probing the energy landscape of activation gating of the bacterial potassium channel KcsA. PLoS Computational Biology. 2013;9(5):e1003058. doi: 10.1371/journal.pcbi.1003058
Beyl S, Depil K, Hohaus A, Weinzinger A, Linder T, Timin E et al. Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of Ca(V)1.2: a cooperative gating model. Pflügers Archiv: European Journal of Physiology. 2012 Okt;464(4):391-401. doi: 10.1007/s00424-012-1144-5
Ke S, Zangerl EM, Weinzinger A. Distinct interactions of Na(+) and Ca(2+) ions with the selectivity filter of the bacterial sodium channel Na(V)Ab. Biochemical and Biophysical Research Communications. 2012;430(4):1272-1276. doi: 10.1016/j.bbrc.2012.12.055
Jansen SA, Kleerekooper I, Hofman ZLM, Kappen IFPM, Weinzinger A, van der Heyden MAG. Grayanotoxin Poisoning: 'Mad Honey Disease' and Beyond. Cardiovascular Toxicology. 2012;12(3):208-215. doi: 10.1007/s12012-012-9162-2
Phillips S, Brammer AE, Rodriguez L, Lim HH, Weinzinger A, Matulef K. Surprises from an Unusual CLC Homolog. Biophysical Journal. 2012;103(9):44-46. doi: 10.1016/j.bpj.2012.08.063
Boukharta L, Keranen H, Weinzinger A, Wallin G, De Groot B, Aqvist J. Computer simulations of structure-activity relationships for HERG channel blockers. Biochemistry. 2011;50(27):6146-6156. doi: 10.1021/bi200173n
Knape K, Linder T, Wolschann KP, Beyer A, Weinzinger A. In silico Analysis of Conformational Changes Induced by Mutation of Aromatic Binding Residues: Consequences for Drug Binding in the hERG K+ Channel. PLoS ONE. 2011;6(12). doi: 10.1371/journal.pone.0028778
Garg V, Weinzinger A, Sachse F, Sanguinetti MC. Molecular Determinants for Activation of Human Ether-a-go-go-related Gene 1 Potassium Channels by 3-Nitro-N-(4-phenoxyphenyl) Benzamide. Molecular Pharmacology. 2011;80(4):630-637. doi: 10.1124/mol.111.073809
Suwattanasophon C, Faller R, Wolschann KP, Weinzinger A. Molecular dynamics simulations on the function of the transmembrane Cav1.2 channel in dependence of the content of cholesterol in the membrane. European Biophysics Journal. 2011;40(Suppl.1):118-118.
Beyl S, Depil K, Hohaus A, Weinzinger A, Timin E, Shabbir W et al. Physicochemical properties of pore residues predict activation gating of Ca(V)1.2: A correlation mutation analysis. Pflügers Archiv: European Journal of Physiology. 2011;461(1):53-63. doi: 10.1007/s00424-010-0885-2
Depil K, Beyl S, Weinzinger A, Hohaus A, Timin E, Hering S. Timothy mutation disrupts the link between activation and inactivation in Ca(V)1.2 protein. Journal of Biological Chemistry. 2011;286(36):31557-31564. doi: 10.1074/jbc.M111.255273
Karmazinova M, Beyl S, Weinzinger A, Suwattanasophon C, Klugbauer N, Hering S et al. Cysteines in the loop between IS5 and the pore helix of Ca(V)3.1 are essential for channel gating: Cysteines in the loop between IS5 and the pore helix of Ca(V)3.1 are essential for channel gating. Pflügers Archiv: European Journal of Physiology. 2010;460(6):1015-1028. doi: 10.1007/s00424-010-0874-5
de Boer T, Nalos L, Weinzinger A, Kok B, Houtman MJC, Antoons G et al. The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel. British Journal of Pharmacology. 2010;159(7):1532-1541. doi: 10.1111/j.1476-5381.2010.00658.x
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Projects
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Novel approaches to investigate the regulation of G-protein coupled inward rectifier K+ channels by Gβγ
Weinzinger, A. (Projektleiter*in) & Friesacher, T. (Co-Projektleiter*in)
1/08/21 → 31/07/24
Projekt: Forschungsförderung
PROSTAGLANDINES - POTENTIAL THERAPEUTICS FOR DEND SYNDROME?
Weinzinger, A. (Projektleiter*in)
1/12/20 → 30/07/23
Projekt: Forschungsförderung
hERG K+ Channel activators
Weinzinger, A. (Projektleiter*in)
4/11/14 → 4/11/15
Projekt: Forschungsförderung
hEAG1 channel blockers
Weinzinger, A. (Projektleiter*in)
15/03/14 → 14/03/15
Projekt: Forschungsförderung
Molekulare Arzneistoff-Targets
Hering, S. (Projektleiter*in), Ecker, G. (Co-Projektleiter*in), Maulide, N. (Co-Projektleiter*in), Weinzinger, A. (Co-Projektleiter*in) & Gonzalez Herrero, L. (Co-Projektleiter*in)
1/12/10 → 31/12/22
Projekt: Forschungsförderung
hERG potassium channel
Weinzinger, A. (Projektleiter*in)
27/10/10 → 31/12/11
Projekt: Forschungsförderung
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