We strive to gain mechanistic insights into the dynamics of protein networks underlying vertebrate somatosensation in health, development (aging), and disease (chronic pain) – an endeavor, which lies at the heart of both understanding the molecular signature of chronic pain and identifying novel drug targets.

Drug Screening

We aim to better understand the etiology and pathophysiology of cerebrovascular disease and brain aging to identify novel druggable targets and to develop innovative therapies for prevention, cytoprotection, regeneration, and recovery of motor and cognitive function.

Our research focuses on ion channel structure and dynamics using computational methods. A major goal is to identify drug candidates for rare ion channel diseases. Hypotheses developed by our computational approaches are tested in close collaboration with experimental laboratories.